Home Medication antibacterial
Home Medication antibacterial

cotrimoxazol (sulfamethoxazol + trimethoprim)

J - Antiinfectives For Systemic Use -> J01 - Antibacterials For Systemic Use -> J01E - Sulfonamides And Trimethoprim -> J01EE - Combinations Of Sulfonamides And Trimethoprim, Incl. Derivatives -> J01EE01 - Sulfamethoxazole And Trimethoprim
Administration category: Free Medicine group: antibacterial File parts: sulfamethoxazol trimethoprim Brand name: Bactrimel

Safety margins

≥ 18 years
Weight ROA Dosage
ROA:
 po 		Dosage:
 min. 400/80mg 1 dd to max. 1600/320mg 3 dd
ROA:
 iv 		Dosage:
 min. 400/80mg 1 dd to max. 1600/320mg 3 dd

Kidney function

≥ 18 years
ROA GFR Dosage Interval Comments
ROA: po
GFR:
 10 - 30 		Dosage:
 50% 		Interval:
 12 Hours 		Comments:
 eerste dag de standaarddosering
GFR:
 <10 		Dosage:
 do not prescribe
ROA: iv
GFR:
 10 - 30 		Dosage:
 50% 		Interval:
 12 Hours 		Comments:
 eerste dag de standaarddosering
GFR:
 <10 		Dosage:
 do not prescribe

Notes GFR general:

Creatinineklaring kleiner dan 30 ml/min:

-Behandeling van PCP: eerste dag de standaarddosering van 1920 mg 3x per dag, vervolgens onderhoudsdosering van 1920 mg 2x per dag. Controleer i.o.m. apotheker de spiegel van sulfamethoxazol, acetylsulfamethoxazol en trimetoprim (zie TDM pagina cotrimoxazol).

-Profylaxe van PCP: eerste dag de standaarddosering van 960 mg 1x per dag, vervolgens onderhoudsdosering 480 mg 1x per dag.

-Overige infecties: eerste dag de standaarddosering van 960 mg 2x per dag, vervolgens onderhoudsdosering van 480 mg 2x per dag of 960 mg 2x per dag.

Renal elimination: 20%

Renal function-replacement therapy

CAPD: Conform adviezen bij 'Opmerkingen GFR algemeen'

Hemo dialysis: Conform adviezen bij 'Opmerkingen GFR algemeen'

CAV / VVHD: eerste dag de standaarddosering van 960 mg 2x per dag, vervolgens 480 mg 2dd of 960 mg 1dd. Behandeling PCP: eerste 3 dagen 1920 mg 3x per dag, daarna 1920 mg 2x per dag, volg plasmapiegel. Profylaxe PCP: zie boven. Controleer i.o.m. apotheker de spiegels

Interactions

Interaction with (ATC): Expected effect:
Interaction with (ATC):
 L04AD01 - Ciclosporin 		Expected effect:
 verlaging ciclosporineconcentratie in volbloed en verhoogde kans op nefrotoxiciteit
Interaction with (ATC):
 N03AB02 - Phenytoin 		Expected effect:
 verhoging plasmaconcentratie fenytoine
Interaction with (ATC):
 B03BB01 - Folic Acid 		Expected effect:
 vermindering werking foliumzuur
Interaction with (ATC):
 L01BA01 - Methotrexate 		Expected effect:
 verhoging plasmaconcentratie methotrexaat
Interaction with (ATC):
 B01AA - Vitamin K Antagonists 		Expected effect:
 versterking effect orale anticoagulantia

Pregnancy

Due to the expiration of the alphanumeric classification for use in pregnancy and lactation, reference is made to the current, online information of the Teratology Information Service (TIS) of LAREB:

For individual advice, consult an expert on site.
TDM Alert
Metadata

Swab vid: M-500874.3
Updated: 11/24/2025 - 14:47
Status: Published

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